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In: Proc. 3rd European Congress "Achievements in Space Medicine into Healthcare Practice and Industry", Berlin, 315–323 (2005)
A New Quantitative Approach for Measuring Changes of 3D Structures in Trabecular Bone
N. Marwan, J. Kurths, P. Saparin, J. S. ThomsenA novel approach which is based on 3D complexity measures was developed in order to quantify the spatial geometrical properties of trabecular bone. These non-destructive measures are able to evaluate different aspects of the organization and complexity of the architecture of trabecular bone, such as complexity of its surface, node complexity, or trabecular bone surface curvature. Their application to 3D μCT images of human proximal tibiae of various osteoporotic stages illustrates the abilities of these measures. The outcome of the bone architecture evaluation by the complexity measures was compared with and validated by the results provided by traditional 2D static histomorphometry. Finally, it can be concluded that this new approach, which was originally designed for quantification of microgravity induced bone loss can be directly applied for diagnosing pathological changes in bone structure in patients as well as to monitor the progress of medical treatment regimens.
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