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The New England Journal of Medicine, 340(13), 1012–1020 (1999) http://content.nejm.org/cgi/content/extract/340/13/1012
Disease-causing mutations often reveal key pathways of physiologic regulation and their underlying molecular mechanisms. Mutations in the trimeric guanine nucleotide-binding proteins (G proteins), which relay signals initiated by photons, odorants, and a host of hormones and neurotransmitters, cause many diseases. For the most part, the diseases are confined to a set of fascinating but rare endocrine disorders (Table 1). A recent study suggests that mutations in G proteins can also lead to essential hypertension. If this study is correct, hypertension may be one of several common disorders caused by defects in this ubiquitous family of signaling …
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