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Journal of Bone and Mineral Research, 14(3), 336–341 (1999), DOI:10.1359/jbmr.1999.14.3.336
For decades, the quest for a more complete insight into mechanisms of bone disease has promoted the development of in vitro systems that model the two main cell types responsible for bone formation and remodeling, osteoblasts and osteoclasts. While generating an unprecedented explosion of biological information, osteoblastic models have been both diverse and controversial. Since the 1980s, a reappraisal of earlier studies on the biology of bone marrow stromal cells as related to the origin and differentiation of osteoblasts have led to ever-increasing current attention to their use and value in bone biology and disease. Significant advances in the pathophysiology of osteoporosis, for example, were enabled by this shift in focus from purportedly "osteoblastic" models to marrow stromal cells proper.
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